| Pittsburgh to Southern Pines (North Carolina) | 363.87 mi (585.60 km) |
| Pittsburgh to Southfield (Michigan) | 220.71 mi (355.19 km) |
| Pittsburgh to Southgate (Michigan) | 207.22 mi (333.49 km) |
| Pittsburgh to Southlake (Texas) | 1,080.19 mi (1,738.41 km) |
| Pittsburgh to Spanaway (Washington) | 2,139.64 mi (3,443.42 km) |
| Pittsburgh to Spanish Fork (Utah) | 1,660.30 mi (2,672.00 km) |
| Pittsburgh to Spanish Lake (Missouri) | 556.06 mi (894.89 km) |
| Pittsburgh to Spanish Springs (Nevada) | 2,082.23 mi (3,351.02 km) |
| Pittsburgh to Sparks (Nevada) | 2,086.08 mi (3,357.22 km) |
| Pittsburgh to Spartanburg (South Carolina) | 394.34 mi (634.62 km) |
| Pittsburgh to Spearfish (South Dakota) | 1,242.09 mi (1,998.96 km) |
| Pittsburgh to Speedway (Indiana) | 334.31 mi (538.02 km) |
| Pittsburgh to Spencer (Iowa) | 802.65 mi (1,291.74 km) |
| Pittsburgh to Spokane (Washington) | 1,905.51 mi (3,066.63 km) |
| Pittsburgh to Spokane Valley (Washington) | 1,896.28 mi (3,051.76 km) |
