| Pittsburgh to Smyrna (Delaware) | 244.77 mi (393.92 km) |
| Pittsburgh to Smyrna (Georgia) | 518.45 mi (834.36 km) |
| Pittsburgh to Smyrna (Tennessee) | 470.82 mi (757.71 km) |
| Pittsburgh to Snellville (Georgia) | 505.92 mi (814.20 km) |
| Pittsburgh to Snoqualmie (Washington) | 2,110.95 mi (3,397.24 km) |
| Pittsburgh to Snyder (Texas) | 1,274.18 mi (2,050.60 km) |
| Pittsburgh to Socastee (South Carolina) | 469.59 mi (755.73 km) |
| Pittsburgh to Socorro (Texas) | 1,581.76 mi (2,545.60 km) |
| Pittsburgh to Soddy-Daisy (Tennessee) | 456.58 mi (734.79 km) |
| Pittsburgh to Solana Beach (California) | 2,111.17 mi (3,397.60 km) |
| Pittsburgh to Soledad (California) | 2,235.05 mi (3,596.97 km) |
| Pittsburgh to Solon (Ohio) | 100.60 mi (161.90 km) |
| Pittsburgh to Somers Point (New Jersey) | 295.05 mi (474.83 km) |
| Pittsburgh to Somerset (Kentucky) | 340.67 mi (548.26 km) |
| Pittsburgh to Somerset (New Jersey) | 287.77 mi (463.12 km) |
