| Pittsburgh to Seymour (Tennessee) | 376.39 mi (605.74 km) |
| Pittsburgh to Shady Hills (Florida) | 844.27 mi (1,358.71 km) |
| Pittsburgh to Shafter (California) | 2,146.25 mi (3,454.05 km) |
| Pittsburgh to Shaker Heights (Ohio) | 108.86 mi (175.19 km) |
| Pittsburgh to Shakopee (Minnesota) | 747.85 mi (1,203.55 km) |
| Pittsburgh to Sharon (Pennsylvania) | 61.32 mi (98.69 km) |
| Pittsburgh to Sharonville (Ohio) | 248.19 mi (399.42 km) |
| Pittsburgh to Shasta Lake (California) | 2,203.70 mi (3,546.51 km) |
| Pittsburgh to Shawnee (Kansas) | 793.28 mi (1,276.66 km) |
| Pittsburgh to Shawnee (Oklahoma) | 988.69 mi (1,591.14 km) |
| Pittsburgh to Sheboygan (Wisconsin) | 458.11 mi (737.26 km) |
| Pittsburgh to Shelby (North Carolina) | 365.91 mi (588.87 km) |
| Pittsburgh to Shelbyville (Indiana) | 313.43 mi (504.42 km) |
| Pittsburgh to Shelbyville (Kentucky) | 320.28 mi (515.44 km) |
| Pittsburgh to Shelbyville (Tennessee) | 490.59 mi (789.54 km) |
