| Pittsburgh to Scottsboro (Alabama) | 520.34 mi (837.41 km) |
| Pittsburgh to Scottsdale (Arizona) | 1,808.21 mi (2,910.04 km) |
| Pittsburgh to Scranton (Pennsylvania) | 234.72 mi (377.74 km) |
| Pittsburgh to Seabrook (Maryland) | 194.35 mi (312.77 km) |
| Pittsburgh to Seabrook (Texas) | 1,132.21 mi (1,822.12 km) |
| Pittsburgh to Seaford (New York) | 340.68 mi (548.27 km) |
| Pittsburgh to Seagoville (Texas) | 1,062.92 mi (1,710.60 km) |
| Pittsburgh to Seal Beach (California) | 2,132.34 mi (3,431.67 km) |
| Pittsburgh to Searcy (Arkansas) | 734.38 mi (1,181.86 km) |
| Pittsburgh to Seaside (California) | 2,255.77 mi (3,630.32 km) |
| Pittsburgh to SeaTac (Washington) | 2,132.54 mi (3,431.99 km) |
| Pittsburgh to Seattle (Washington) | 2,133.19 mi (3,433.04 km) |
| Pittsburgh to Sebastian (Florida) | 875.02 mi (1,408.21 km) |
| Pittsburgh to Sebring (Florida) | 899.58 mi (1,447.74 km) |
| Pittsburgh to Secaucus (New Jersey) | 310.85 mi (500.27 km) |
