| Pittsburgh to Santa Rosa (California) | 2,261.87 mi (3,640.12 km) |
| Pittsburgh to Santaquin (Utah) | 1,670.16 mi (2,687.86 km) |
| Pittsburgh to Santee (California) | 2,100.93 mi (3,381.12 km) |
| Pittsburgh to Sapulpa (Oklahoma) | 925.55 mi (1,489.53 km) |
| Pittsburgh to Saraland (Alabama) | 803.70 mi (1,293.43 km) |
| Pittsburgh to Sarasota (Florida) | 916.96 mi (1,475.71 km) |
| Pittsburgh to Sarasota Springs (Florida) | 918.40 mi (1,478.02 km) |
| Pittsburgh to Saratoga (California) | 2,251.78 mi (3,623.89 km) |
| Pittsburgh to Saratoga Springs (New York) | 367.35 mi (591.20 km) |
| Pittsburgh to Saratoga Springs (Utah) | 1,671.46 mi (2,689.95 km) |
| Pittsburgh to Sartell (Minnesota) | 801.96 mi (1,290.62 km) |
| Pittsburgh to Satellite Beach (Florida) | 847.93 mi (1,364.62 km) |
| Pittsburgh to Sauk Rapids (Minnesota) | 798.43 mi (1,284.95 km) |
| Pittsburgh to Sault Ste. Marie (Michigan) | 471.91 mi (759.47 km) |
| Pittsburgh to Savage (Minnesota) | 742.11 mi (1,194.32 km) |
