| Pittsburgh to Sanford (Maine) | 516.42 mi (831.09 km) |
| Pittsburgh to Sanford (North Carolina) | 344.92 mi (555.09 km) |
| Pittsburgh to Sanger (California) | 2,135.81 mi (3,437.26 km) |
| Pittsburgh to Santa Ana (California) | 2,122.86 mi (3,416.41 km) |
| Pittsburgh to Santa Barbara (California) | 2,200.64 mi (3,541.59 km) |
| Pittsburgh to Santa Clara (California) | 2,246.61 mi (3,615.56 km) |
| Pittsburgh to Santa Clara (Oregon) | 2,195.45 mi (3,533.24 km) |
| Pittsburgh to Santa Clarita (California) | 2,136.61 mi (3,438.54 km) |
| Pittsburgh to Santa Cruz (California) | 2,258.74 mi (3,635.09 km) |
| Pittsburgh to Santa Fe (New Mexico) | 1,447.24 mi (2,329.11 km) |
| Pittsburgh to Santa Fe (Texas) | 1,144.65 mi (1,842.13 km) |
| Pittsburgh to Santa Fe Springs (California) | 2,126.93 mi (3,422.96 km) |
| Pittsburgh to Santa Maria (California) | 2,225.32 mi (3,581.30 km) |
| Pittsburgh to Santa Monica (California) | 2,146.45 mi (3,454.37 km) |
| Pittsburgh to Santa Paula (California) | 2,168.22 mi (3,489.41 km) |
