| Pittsburgh to San Luis Obispo (California) | 2,228.60 mi (3,586.59 km) |
| Pittsburgh to San Marcos (California) | 2,102.72 mi (3,384.01 km) |
| Pittsburgh to San Marcos (Texas) | 1,245.85 mi (2,005.00 km) |
| Pittsburgh to San Marino (California) | 2,124.41 mi (3,418.91 km) |
| Pittsburgh to San Mateo (California) | 2,260.36 mi (3,637.70 km) |
| Pittsburgh to San Pablo (California) | 2,253.09 mi (3,626.00 km) |
| Pittsburgh to San Rafael (California) | 2,261.81 mi (3,640.03 km) |
| Pittsburgh to San Ramon (California) | 2,236.30 mi (3,598.98 km) |
| Pittsburgh to San Tan Valley (Arizona) | 1,807.11 mi (2,908.27 km) |
| Pittsburgh to Sand Springs (Oklahoma) | 923.45 mi (1,486.15 km) |
| Pittsburgh to Sandusky (Ohio) | 158.37 mi (254.87 km) |
| Pittsburgh to Sandy (Oregon) | 2,142.00 mi (3,447.21 km) |
| Pittsburgh to Sandy (Utah) | 1,665.27 mi (2,680.00 km) |
| Pittsburgh to Sandy Springs (Georgia) | 510.10 mi (820.93 km) |
| Pittsburgh to Sanford (Florida) | 808.33 mi (1,300.89 km) |
