| Pittsburgh to Oskaloosa (Iowa) | 663.74 mi (1,068.18 km) |
| Pittsburgh to Oswego (Illinois) | 443.78 mi (714.19 km) |
| Pittsburgh to Oswego (New York) | 274.19 mi (441.27 km) |
| Pittsburgh to Otsego (Minnesota) | 766.00 mi (1,232.75 km) |
| Pittsburgh to Ottawa (Illinois) | 466.29 mi (750.43 km) |
| Pittsburgh to Ottawa (Kansas) | 823.58 mi (1,325.43 km) |
| Pittsburgh to Ottumwa (Iowa) | 652.14 mi (1,049.52 km) |
| Pittsburgh to Overland (Missouri) | 566.11 mi (911.07 km) |
| Pittsburgh to Overland Park (Kansas) | 788.82 mi (1,269.48 km) |
| Pittsburgh to Overlea (Maryland) | 197.80 mi (318.33 km) |
| Pittsburgh to Oviedo (Florida) | 816.92 mi (1,314.71 km) |
| Pittsburgh to Owasso (Oklahoma) | 904.05 mi (1,454.93 km) |
| Pittsburgh to Owatonna (Minnesota) | 722.16 mi (1,162.21 km) |
| Pittsburgh to Owensboro (Kentucky) | 425.21 mi (684.30 km) |
| Pittsburgh to Owings Mills (Maryland) | 183.09 mi (294.65 km) |
