| Pittsburgh to Orangeburg (South Carolina) | 482.49 mi (776.49 km) |
| Pittsburgh to Orangevale (California) | 2,180.20 mi (3,508.69 km) |
| Pittsburgh to Orchards (Washington) | 2,152.48 mi (3,464.09 km) |
| Pittsburgh to Orcutt (California) | 2,225.89 mi (3,582.22 km) |
| Pittsburgh to Oregon (Ohio) | 198.60 mi (319.61 km) |
| Pittsburgh to Oregon (Wisconsin) | 514.84 mi (828.55 km) |
| Pittsburgh to Oregon City (Oregon) | 2,158.00 mi (3,472.96 km) |
| Pittsburgh to Orem (Utah) | 1,660.88 mi (2,672.93 km) |
| Pittsburgh to Orinda (California) | 2,246.35 mi (3,615.16 km) |
| Pittsburgh to Orland Park (Illinois) | 418.73 mi (673.89 km) |
| Pittsburgh to Orlando (Florida) | 830.12 mi (1,335.94 km) |
| Pittsburgh to Ormond Beach (Florida) | 772.40 mi (1,243.06 km) |
| Pittsburgh to Oro Valley (Arizona) | 1,799.48 mi (2,895.99 km) |
| Pittsburgh to Oroville (California) | 2,182.49 mi (3,512.37 km) |
| Pittsburgh to Oshkosh (Wisconsin) | 503.82 mi (810.81 km) |
