| Pittsburgh to Enterprise (Nevada) | 1,924.74 mi (3,097.57 km) |
| Pittsburgh to Enumclaw (Washington) | 2,118.91 mi (3,410.05 km) |
| Pittsburgh to Ephrata (Pennsylvania) | 200.73 mi (323.05 km) |
| Pittsburgh to Erie (Colorado) | 1,317.74 mi (2,120.70 km) |
| Pittsburgh to Erie (Pennsylvania) | 115.98 mi (186.65 km) |
| Pittsburgh to Erlanger (Kentucky) | 264.08 mi (425.00 km) |
| Pittsburgh to Escanaba (Michigan) | 512.75 mi (825.19 km) |
| Pittsburgh to Escondido (California) | 2,097.37 mi (3,375.39 km) |
| Pittsburgh to Española (New Mexico) | 1,443.46 mi (2,323.03 km) |
| Pittsburgh to Essex (Maryland) | 203.07 mi (326.81 km) |
| Pittsburgh to Essex Junction (Vermont) | 447.67 mi (720.46 km) |
| Pittsburgh to Estelle (Louisiana) | 927.67 mi (1,492.95 km) |
| Pittsburgh to Estero (Florida) | 973.74 mi (1,567.08 km) |
| Pittsburgh to Euclid (Ohio) | 113.07 mi (181.98 km) |
| Pittsburgh to Eufaula (Alabama) | 655.87 mi (1,055.53 km) |
