| Piqua to Southern Pines (North Carolina) | 432.76 mi (696.45 km) |
| Piqua to Southfield (Michigan) | 168.61 mi (271.36 km) |
| Piqua to Southgate (Michigan) | 151.85 mi (244.38 km) |
| Piqua to Southlake (Texas) | 870.51 mi (1,400.95 km) |
| Piqua to Spanaway (Washington) | 1,948.05 mi (3,135.08 km) |
| Piqua to Spanish Fork (Utah) | 1,441.48 mi (2,319.84 km) |
| Piqua to Spanish Lake (Missouri) | 331.64 mi (533.72 km) |
| Piqua to Spanish Springs (Nevada) | 1,865.38 mi (3,002.04 km) |
| Piqua to Sparks (Nevada) | 1,869.07 mi (3,007.97 km) |
| Piqua to Spartanburg (South Carolina) | 381.46 mi (613.90 km) |
| Piqua to Spearfish (South Dakota) | 1,040.92 mi (1,675.20 km) |
| Piqua to Speedway (Indiana) | 108.94 mi (175.32 km) |
| Piqua to Spencer (Iowa) | 599.52 mi (964.83 km) |
| Piqua to Spokane (Washington) | 1,716.72 mi (2,762.80 km) |
| Piqua to Spokane Valley (Washington) | 1,707.50 mi (2,747.96 km) |
