| Picayune to Superior (Colorado) | 1,086.28 mi (1,748.20 km) |
| Picayune to Superior (Wisconsin) | 1,124.09 mi (1,809.04 km) |
| Picayune to Surprise (Arizona) | 1,347.97 mi (2,169.36 km) |
| Picayune to Susanville (California) | 1,858.32 mi (2,990.67 km) |
| Picayune to Sussex (Wisconsin) | 874.38 mi (1,407.19 km) |
| Picayune to Suwanee (Georgia) | 407.59 mi (655.96 km) |
| Picayune to Swansea (Illinois) | 554.31 mi (892.08 km) |
| Picayune to Sweetwater (Florida) | 654.29 mi (1,052.97 km) |
| Picayune to Sweetwater (Texas) | 646.21 mi (1,039.98 km) |
| Picayune to Sycamore (Illinois) | 793.95 mi (1,277.74 km) |
| Picayune to Sylacauga (Alabama) | 271.10 mi (436.29 km) |
| Picayune to Sylvania (Ohio) | 840.41 mi (1,352.50 km) |
| Picayune to Syosset (New York) | 1,149.38 mi (1,849.75 km) |
| Picayune to Syracuse (New York) | 1,140.37 mi (1,835.24 km) |
| Picayune to Syracuse (Utah) | 1,445.11 mi (2,325.68 km) |
