| Picayune to Southern Pines (North Carolina) | 676.85 mi (1,089.28 km) |
| Picayune to Southfield (Michigan) | 898.12 mi (1,445.38 km) |
| Picayune to Southgate (Michigan) | 882.41 mi (1,420.10 km) |
| Picayune to Southlake (Texas) | 470.03 mi (756.45 km) |
| Picayune to Spanaway (Washington) | 2,078.69 mi (3,345.33 km) |
| Picayune to Spanish Fork (Utah) | 1,398.71 mi (2,251.00 km) |
| Picayune to Spanish Lake (Missouri) | 571.26 mi (919.35 km) |
| Picayune to Spanish Springs (Nevada) | 1,798.90 mi (2,895.04 km) |
| Picayune to Sparks (Nevada) | 1,800.23 mi (2,897.20 km) |
| Picayune to Spartanburg (South Carolina) | 543.45 mi (874.61 km) |
| Picayune to Spearfish (South Dakota) | 1,233.54 mi (1,985.19 km) |
| Picayune to Speedway (Indiana) | 668.35 mi (1,075.60 km) |
| Picayune to Spencer (Iowa) | 922.22 mi (1,484.17 km) |
| Picayune to Spokane (Washington) | 1,884.24 mi (3,032.39 km) |
| Picayune to Spokane Valley (Washington) | 1,876.02 mi (3,019.16 km) |
