| Picayune to Santa Rosa (California) | 1,947.42 mi (3,134.08 km) |
| Picayune to Santaquin (Utah) | 1,402.83 mi (2,257.63 km) |
| Picayune to Santee (California) | 1,609.22 mi (2,589.79 km) |
| Picayune to Sapulpa (Oklahoma) | 529.91 mi (852.80 km) |
| Picayune to Saraland (Alabama) | 95.91 mi (154.36 km) |
| Picayune to Sarasota (Florida) | 484.12 mi (779.12 km) |
| Picayune to Sarasota Springs (Florida) | 488.81 mi (786.67 km) |
| Picayune to Saratoga (California) | 1,902.86 mi (3,062.36 km) |
| Picayune to Saratoga Springs (New York) | 1,230.19 mi (1,979.81 km) |
| Picayune to Saratoga Springs (Utah) | 1,418.14 mi (2,282.28 km) |
| Picayune to Sartell (Minnesota) | 1,070.86 mi (1,723.38 km) |
| Picayune to Satellite Beach (Florida) | 569.74 mi (916.90 km) |
| Picayune to Sauk Rapids (Minnesota) | 1,068.65 mi (1,719.83 km) |
| Picayune to Sault Ste. Marie (Michigan) | 1,137.96 mi (1,831.38 km) |
| Picayune to Savage (Minnesota) | 1,002.90 mi (1,614.02 km) |
