| Picayune to Olympia (Washington) | 2,098.00 mi (3,376.40 km) |
| Picayune to Olympia Heights (Florida) | 658.26 mi (1,059.36 km) |
| Picayune to Omaha (Nebraska) | 822.32 mi (1,323.40 km) |
| Picayune to On Top of the World Designated Place (Florida) | 453.48 mi (729.81 km) |
| Picayune to Onalaska (Wisconsin) | 926.63 mi (1,491.26 km) |
| Picayune to Oneida (New York) | 1,159.51 mi (1,866.06 km) |
| Picayune to Oneonta (New York) | 1,152.94 mi (1,855.47 km) |
| Picayune to Ontario (California) | 1,644.36 mi (2,646.34 km) |
| Picayune to Ontario (Oregon) | 1,754.42 mi (2,823.46 km) |
| Picayune to Opa-locka (Florida) | 656.26 mi (1,056.16 km) |
| Picayune to Opelika (Alabama) | 292.44 mi (470.63 km) |
| Picayune to Opelousas (Louisiana) | 143.38 mi (230.75 km) |
| Picayune to Orange (California) | 1,656.60 mi (2,666.04 km) |
| Picayune to Orange (Texas) | 245.44 mi (395.00 km) |
| Picayune to Orange City (Florida) | 514.86 mi (828.58 km) |
