| Picayune to Enterprise (Nevada) | 1,519.15 mi (2,444.83 km) |
| Picayune to Enumclaw (Washington) | 2,062.48 mi (3,319.24 km) |
| Picayune to Ephrata (Pennsylvania) | 1,009.00 mi (1,623.82 km) |
| Picayune to Erie (Colorado) | 1,084.87 mi (1,745.93 km) |
| Picayune to Erie (Pennsylvania) | 960.94 mi (1,546.48 km) |
| Picayune to Erlanger (Kentucky) | 652.78 mi (1,050.55 km) |
| Picayune to Escanaba (Michigan) | 1,060.46 mi (1,706.64 km) |
| Picayune to Escondido (California) | 1,613.81 mi (2,597.17 km) |
| Picayune to Española (New Mexico) | 1,018.20 mi (1,638.63 km) |
| Picayune to Essex (Maryland) | 961.90 mi (1,548.03 km) |
| Picayune to Essex Junction (Vermont) | 1,319.17 mi (2,123.00 km) |
| Picayune to Estelle (Louisiana) | 53.99 mi (86.89 km) |
| Picayune to Estero (Florida) | 555.91 mi (894.65 km) |
| Picayune to Euclid (Ohio) | 888.46 mi (1,429.84 km) |
| Picayune to Eufaula (Alabama) | 283.61 mi (456.43 km) |
