| Penrith to Spello | 1,064.49 mi (1,713.13 km) |
| Penrith to Spilamberto | 929.62 mi (1,496.08 km) |
| Penrith to Spilimbergo | 903.30 mi (1,453.71 km) |
| Penrith to Spinea | 912.45 mi (1,468.44 km) |
| Penrith to Spoleto | 1,078.00 mi (1,734.88 km) |
| Penrith to Spoltore | 1,138.04 mi (1,831.50 km) |
| Penrith to Spresiano | 900.19 mi (1,448.71 km) |
| Penrith to Squinzano | 1,371.26 mi (2,206.82 km) |
| Penrith to Statte | 1,337.07 mi (2,151.81 km) |
| Penrith to Stezzano | 827.98 mi (1,332.51 km) |
| Penrith to Strada | 991.75 mi (1,596.07 km) |
| Penrith to Stradella | 849.86 mi (1,367.73 km) |
| Penrith to Striano | 1,243.33 mi (2,000.95 km) |
| Penrith to Subiaco | 1,136.89 mi (1,829.65 km) |
| Penrith to Sulmona | 1,154.45 mi (1,857.91 km) |
