| Penrith to Sacile | 898.84 mi (1,446.54 km) |
| Penrith to Sala Consilina | 1,297.60 mi (2,088.28 km) |
| Penrith to Salemi | 1,374.32 mi (2,211.76 km) |
| Penrith to Salerno | 1,256.77 mi (2,022.58 km) |
| Penrith to Salo | 856.67 mi (1,378.68 km) |
| Penrith to Salsomaggiore Terme | 884.08 mi (1,422.79 km) |
| Penrith to Saluzzo | 828.36 mi (1,333.12 km) |
| Penrith to Salzano | 908.95 mi (1,462.82 km) |
| Penrith to Samarate | 805.28 mi (1,295.98 km) |
| Penrith to San Benedetto del Tronto | 1,102.83 mi (1,774.84 km) |
| Penrith to San Biagio di Callalta | 909.39 mi (1,463.52 km) |
| Penrith to San Bonifacio | 890.14 mi (1,432.55 km) |
| Penrith to San Casciano in Val di Pesa | 983.85 mi (1,583.35 km) |
| Penrith to San Cataldo | 1,424.79 mi (2,292.98 km) |
| Penrith to San Cesareo | 1,135.06 mi (1,826.71 km) |
