| Pembroke Dock to Southern Pines (North Carolina) | 3,730.09 mi (6,003.00 km) |
| Pembroke Dock to Southfield (Michigan) | 3,558.39 mi (5,726.67 km) |
| Pembroke Dock to Southgate (Michigan) | 3,568.09 mi (5,742.29 km) |
| Pembroke Dock to Southlake (Texas) | 4,559.67 mi (7,338.08 km) |
| Pembroke Dock to Spanaway (Washington) | 4,674.82 mi (7,523.39 km) |
| Pembroke Dock to Spanish Fork (Utah) | 4,720.71 mi (7,597.25 km) |
| Pembroke Dock to Spanish Lake (Missouri) | 4,000.10 mi (6,437.54 km) |
| Pembroke Dock to Spanish Springs (Nevada) | 5,007.24 mi (8,058.38 km) |
| Pembroke Dock to Sparks (Nevada) | 5,013.35 mi (8,068.21 km) |
| Pembroke Dock to Spartanburg (South Carolina) | 3,846.51 mi (6,190.36 km) |
| Pembroke Dock to Spearfish (South Dakota) | 4,228.59 mi (6,805.25 km) |
| Pembroke Dock to Speedway (Indiana) | 3,796.86 mi (6,110.45 km) |
| Pembroke Dock to Spencer (Iowa) | 3,983.66 mi (6,411.09 km) |
| Pembroke Dock to Spokane (Washington) | 4,500.64 mi (7,243.08 km) |
| Pembroke Dock to Spokane Valley (Washington) | 4,495.05 mi (7,234.08 km) |
