| Parkway to Storm Lake (Iowa) | 1,401.43 mi (2,255.39 km) |
| Parkway to Storrs (Connecticut) | 2,572.74 mi (4,140.43 km) |
| Parkway to Stoughton (Wisconsin) | 1,704.60 mi (2,743.30 km) |
| Parkway to Stow (Ohio) | 2,112.42 mi (3,399.62 km) |
| Parkway to Streamwood (Illinois) | 1,759.96 mi (2,832.39 km) |
| Parkway to Streator (Illinois) | 1,730.70 mi (2,785.30 km) |
| Parkway to Streetsboro (Ohio) | 2,116.36 mi (3,405.95 km) |
| Parkway to Strongsville (Ohio) | 2,090.68 mi (3,364.62 km) |
| Parkway to Stuart (Florida) | 2,492.86 mi (4,011.88 km) |
| Parkway to Stuarts Draft (Virginia) | 2,280.67 mi (3,670.39 km) |
| Parkway to Sturgis (Michigan) | 1,902.59 mi (3,061.93 km) |
| Parkway to Suamico (Wisconsin) | 1,763.73 mi (2,838.44 km) |
| Parkway to Sudley (Virginia) | 2,348.71 mi (3,779.88 km) |
| Parkway to Suffern (New York) | 2,486.67 mi (4,001.91 km) |
| Parkway to Suffolk (Virginia) | 2,431.98 mi (3,913.90 km) |
