| Parkway to Southern Pines (North Carolina) | 2,315.96 mi (3,727.18 km) |
| Parkway to Southfield (Michigan) | 2,008.46 mi (3,232.31 km) |
| Parkway to Southgate (Michigan) | 2,013.02 mi (3,239.65 km) |
| Parkway to Southlake (Texas) | 1,411.21 mi (2,271.12 km) |
| Parkway to Spanaway (Washington) | 596.13 mi (959.38 km) |
| Parkway to Spanish Fork (Utah) | 535.93 mi (862.50 km) |
| Parkway to Spanish Lake (Missouri) | 1,677.92 mi (2,700.35 km) |
| Parkway to Spanish Springs (Nevada) | 124.65 mi (200.60 km) |
| Parkway to Sparks (Nevada) | 119.11 mi (191.69 km) |
| Parkway to Spartanburg (South Carolina) | 2,185.99 mi (3,518.01 km) |
| Parkway to Spearfish (South Dakota) | 999.50 mi (1,608.54 km) |
| Parkway to Speedway (Indiana) | 1,876.31 mi (3,019.63 km) |
| Parkway to Spencer (Iowa) | 1,405.75 mi (2,262.34 km) |
| Parkway to Spokane (Washington) | 664.86 mi (1,070.00 km) |
| Parkway to Spokane Valley (Washington) | 667.67 mi (1,074.51 km) |
