| Parkway to Smyrna (Delaware) | 2,438.89 mi (3,925.01 km) |
| Parkway to Smyrna (Georgia) | 2,070.53 mi (3,332.20 km) |
| Parkway to Smyrna (Tennessee) | 1,917.69 mi (3,086.22 km) |
| Parkway to Snellville (Georgia) | 2,098.41 mi (3,377.06 km) |
| Parkway to Snoqualmie (Washington) | 624.22 mi (1,004.58 km) |
| Parkway to Snyder (Texas) | 1,217.98 mi (1,960.15 km) |
| Parkway to Socastee (South Carolina) | 2,371.82 mi (3,817.08 km) |
| Parkway to Socorro (Texas) | 979.37 mi (1,576.14 km) |
| Parkway to Soddy-Daisy (Tennessee) | 2,004.52 mi (3,225.96 km) |
| Parkway to Solana Beach (California) | 447.08 mi (719.51 km) |
| Parkway to Soledad (California) | 142.19 mi (228.83 km) |
| Parkway to Solon (Ohio) | 2,110.07 mi (3,395.83 km) |
| Parkway to Somers Point (New Jersey) | 2,490.51 mi (4,008.08 km) |
| Parkway to Somerset (Kentucky) | 2,000.47 mi (3,219.45 km) |
| Parkway to Somerset (New Jersey) | 2,477.11 mi (3,986.52 km) |
