| Parkway to Seymour (Tennessee) | 2,067.73 mi (3,327.70 km) |
| Parkway to Shady Hills (Florida) | 2,329.39 mi (3,748.79 km) |
| Parkway to Shafter (California) | 242.81 mi (390.76 km) |
| Parkway to Shaker Heights (Ohio) | 2,103.61 mi (3,385.43 km) |
| Parkway to Shakopee (Minnesota) | 1,499.75 mi (2,413.62 km) |
| Parkway to Sharon (Pennsylvania) | 2,159.88 mi (3,475.99 km) |
| Parkway to Sharonville (Ohio) | 1,978.90 mi (3,184.74 km) |
| Parkway to Shasta Lake (California) | 158.46 mi (255.01 km) |
| Parkway to Shawnee (Kansas) | 1,430.88 mi (2,302.77 km) |
| Parkway to Shawnee (Oklahoma) | 1,365.72 mi (2,197.92 km) |
| Parkway to Sheboygan (Wisconsin) | 1,779.23 mi (2,863.39 km) |
| Parkway to Shelby (North Carolina) | 2,199.00 mi (3,538.95 km) |
| Parkway to Shelbyville (Indiana) | 1,903.74 mi (3,063.78 km) |
| Parkway to Shelbyville (Kentucky) | 1,949.89 mi (3,138.04 km) |
| Parkway to Shelbyville (Tennessee) | 1,930.80 mi (3,107.32 km) |
