| Parkway to Scottsboro (Alabama) | 1,970.25 mi (3,170.80 km) |
| Parkway to Scottsdale (Arizona) | 629.58 mi (1,013.21 km) |
| Parkway to Scranton (Pennsylvania) | 2,405.19 mi (3,870.77 km) |
| Parkway to Seabrook (Maryland) | 2,379.32 mi (3,829.15 km) |
| Parkway to Seabrook (Texas) | 1,626.67 mi (2,617.87 km) |
| Parkway to Seaford (New York) | 2,526.38 mi (4,065.81 km) |
| Parkway to Seagoville (Texas) | 1,451.66 mi (2,336.23 km) |
| Parkway to Seal Beach (California) | 378.19 mi (608.63 km) |
| Parkway to Searcy (Arkansas) | 1,650.66 mi (2,656.48 km) |
| Parkway to Seaside (California) | 131.24 mi (211.21 km) |
| Parkway to SeaTac (Washington) | 619.52 mi (997.01 km) |
| Parkway to Seattle (Washington) | 631.78 mi (1,016.75 km) |
| Parkway to Sebastian (Florida) | 2,460.71 mi (3,960.13 km) |
| Parkway to Sebring (Florida) | 2,418.50 mi (3,892.21 km) |
| Parkway to Secaucus (New Jersey) | 2,495.36 mi (4,015.89 km) |
