| Parkway to Sanford (Maine) | 2,625.86 mi (4,225.91 km) |
| Parkway to Sanford (North Carolina) | 2,321.77 mi (3,736.52 km) |
| Parkway to Sanger (California) | 161.94 mi (260.62 km) |
| Parkway to Santa Ana (California) | 384.61 mi (618.97 km) |
| Parkway to Santa Barbara (California) | 297.25 mi (478.38 km) |
| Parkway to Santa Clara (California) | 83.29 mi (134.04 km) |
| Parkway to Santa Clara (Oregon) | 397.71 mi (640.06 km) |
| Parkway to Santa Clarita (California) | 326.32 mi (525.16 km) |
| Parkway to Santa Cruz (California) | 109.77 mi (176.65 km) |
| Parkway to Santa Fe (New Mexico) | 873.83 mi (1,406.30 km) |
| Parkway to Santa Fe (Texas) | 1,628.98 mi (2,621.60 km) |
| Parkway to Santa Fe Springs (California) | 367.68 mi (591.73 km) |
| Parkway to Santa Maria (California) | 252.64 mi (406.58 km) |
| Parkway to Santa Monica (California) | 350.70 mi (564.40 km) |
| Parkway to Santa Paula (California) | 315.58 mi (507.88 km) |
