| Parkway to Oskaloosa (Iowa) | 1,532.30 mi (2,466.00 km) |
| Parkway to Oswego (Illinois) | 1,753.23 mi (2,821.56 km) |
| Parkway to Oswego (New York) | 2,340.92 mi (3,767.35 km) |
| Parkway to Otsego (Minnesota) | 1,497.36 mi (2,409.76 km) |
| Parkway to Ottawa (Illinois) | 1,729.62 mi (2,783.56 km) |
| Parkway to Ottawa (Kansas) | 1,410.29 mi (2,269.64 km) |
| Parkway to Ottumwa (Iowa) | 1,544.71 mi (2,485.98 km) |
| Parkway to Overland (Missouri) | 1,670.38 mi (2,688.21 km) |
| Parkway to Overland Park (Kansas) | 1,438.42 mi (2,314.92 km) |
| Parkway to Overlea (Maryland) | 2,390.49 mi (3,847.13 km) |
| Parkway to Oviedo (Florida) | 2,394.56 mi (3,853.68 km) |
| Parkway to Owasso (Oklahoma) | 1,410.11 mi (2,269.35 km) |
| Parkway to Owatonna (Minnesota) | 1,506.88 mi (2,425.09 km) |
| Parkway to Owensboro (Kentucky) | 1,855.93 mi (2,986.83 km) |
| Parkway to Owings Mills (Maryland) | 2,375.51 mi (3,823.02 km) |
