| Parkway to Orangeburg (South Carolina) | 2,276.36 mi (3,663.46 km) |
| Parkway to Orangevale (California) | 18.05 mi (29.05 km) |
| Parkway to Orchards (Washington) | 499.81 mi (804.37 km) |
| Parkway to Orcutt (California) | 257.23 mi (413.96 km) |
| Parkway to Oregon (Ohio) | 2,005.52 mi (3,227.57 km) |
| Parkway to Oregon (Wisconsin) | 1,696.17 mi (2,729.72 km) |
| Parkway to Oregon City (Oregon) | 476.38 mi (766.66 km) |
| Parkway to Orem (Utah) | 535.03 mi (861.04 km) |
| Parkway to Orinda (California) | 58.18 mi (93.63 km) |
| Parkway to Orland Park (Illinois) | 1,778.09 mi (2,861.55 km) |
| Parkway to Orlando (Florida) | 2,392.21 mi (3,849.90 km) |
| Parkway to Ormond Beach (Florida) | 2,379.26 mi (3,829.05 km) |
| Parkway to Oro Valley (Arizona) | 723.04 mi (1,163.61 km) |
| Parkway to Oroville (California) | 69.39 mi (111.68 km) |
| Parkway to Oshkosh (Wisconsin) | 1,738.09 mi (2,797.19 km) |
