| Panama City to Southern Pines (North Carolina) | 498.61 mi (802.44 km) |
| Panama City to Southfield (Michigan) | 858.10 mi (1,380.97 km) |
| Panama City to Southgate (Michigan) | 840.05 mi (1,351.93 km) |
| Panama City to Southlake (Texas) | 705.57 mi (1,135.51 km) |
| Panama City to Spanaway (Washington) | 2,274.49 mi (3,660.43 km) |
| Panama City to Spanish Fork (Utah) | 1,614.57 mi (2,598.41 km) |
| Panama City to Spanish Lake (Missouri) | 648.60 mi (1,043.82 km) |
| Panama City to Spanish Springs (Nevada) | 2,023.36 mi (3,256.28 km) |
| Panama City to Sparks (Nevada) | 2,025.01 mi (3,258.94 km) |
| Panama City to Spartanburg (South Carolina) | 391.41 mi (629.91 km) |
| Panama City to Spearfish (South Dakota) | 1,399.53 mi (2,252.32 km) |
| Panama City to Speedway (Indiana) | 663.90 mi (1,068.45 km) |
| Panama City to Spencer (Iowa) | 1,037.84 mi (1,670.24 km) |
| Panama City to Spokane (Washington) | 2,070.28 mi (3,331.79 km) |
| Panama City to Spokane Valley (Washington) | 2,061.73 mi (3,318.04 km) |
