| Palm Desert to Southern Pines (North Carolina) | 2,096.02 mi (3,373.21 km) |
| Palm Desert to Southfield (Michigan) | 1,884.63 mi (3,033.01 km) |
| Palm Desert to Southgate (Michigan) | 1,885.00 mi (3,033.62 km) |
| Palm Desert to Southlake (Texas) | 1,109.01 mi (1,784.79 km) |
| Palm Desert to Spanaway (Washington) | 975.71 mi (1,570.25 km) |
| Palm Desert to Spanish Fork (Utah) | 511.74 mi (823.56 km) |
| Palm Desert to Spanish Lake (Missouri) | 1,493.11 mi (2,402.93 km) |
| Palm Desert to Spanish Springs (Nevada) | 447.87 mi (720.78 km) |
| Palm Desert to Sparks (Nevada) | 443.74 mi (714.14 km) |
| Palm Desert to Spartanburg (South Carolina) | 1,957.10 mi (3,149.65 km) |
| Palm Desert to Spearfish (South Dakota) | 1,000.12 mi (1,609.53 km) |
| Palm Desert to Speedway (Indiana) | 1,710.11 mi (2,752.16 km) |
| Palm Desert to Spencer (Iowa) | 1,313.93 mi (2,114.56 km) |
| Palm Desert to Spokane (Washington) | 964.01 mi (1,551.42 km) |
| Palm Desert to Spokane Valley (Washington) | 963.16 mi (1,550.06 km) |
