| Palm Coast to Southern Pines (North Carolina) | 405.13 mi (652.00 km) |
| Palm Coast to Southfield (Michigan) | 900.89 mi (1,449.84 km) |
| Palm Coast to Southgate (Michigan) | 881.90 mi (1,419.29 km) |
| Palm Coast to Southlake (Texas) | 967.61 mi (1,557.21 km) |
| Palm Coast to Spanaway (Washington) | 2,501.43 mi (4,025.66 km) |
| Palm Coast to Spanish Fork (Utah) | 1,860.56 mi (2,994.28 km) |
| Palm Coast to Spanish Lake (Missouri) | 818.17 mi (1,316.72 km) |
| Palm Coast to Spanish Springs (Nevada) | 2,274.83 mi (3,660.99 km) |
| Palm Coast to Sparks (Nevada) | 2,276.73 mi (3,664.04 km) |
| Palm Coast to Spartanburg (South Carolina) | 375.57 mi (604.42 km) |
| Palm Coast to Spearfish (South Dakota) | 1,608.24 mi (2,588.22 km) |
| Palm Coast to Speedway (Indiana) | 763.08 mi (1,228.06 km) |
| Palm Coast to Spencer (Iowa) | 1,214.35 mi (1,954.31 km) |
| Palm Coast to Spokane (Washington) | 2,289.76 mi (3,685.01 km) |
| Palm Coast to Spokane Valley (Washington) | 2,280.98 mi (3,670.88 km) |
