| Painesville to Southern Pines (North Carolina) | 462.20 mi (743.84 km) |
| Painesville to Southfield (Michigan) | 115.27 mi (185.51 km) |
| Painesville to Southgate (Michigan) | 105.64 mi (170.02 km) |
| Painesville to Southlake (Texas) | 1,060.10 mi (1,706.06 km) |
| Painesville to Spanaway (Washington) | 2,041.21 mi (3,285.00 km) |
| Painesville to Spanish Fork (Utah) | 1,582.20 mi (2,546.30 km) |
| Painesville to Spanish Lake (Missouri) | 513.53 mi (826.45 km) |
| Painesville to Spanish Springs (Nevada) | 2,000.93 mi (3,220.19 km) |
| Painesville to Sparks (Nevada) | 2,004.97 mi (3,226.69 km) |
| Painesville to Spartanburg (South Carolina) | 469.85 mi (756.14 km) |
| Painesville to Spearfish (South Dakota) | 1,150.23 mi (1,851.12 km) |
| Painesville to Speedway (Indiana) | 293.38 mi (472.15 km) |
| Painesville to Spencer (Iowa) | 714.74 mi (1,150.25 km) |
| Painesville to Spokane (Washington) | 1,806.23 mi (2,906.85 km) |
| Painesville to Spokane Valley (Washington) | 1,797.00 mi (2,892.00 km) |
