| Oro Valley to Southern Pines (North Carolina) | 1,815.10 mi (2,921.11 km) |
| Oro Valley to Southfield (Michigan) | 1,661.57 mi (2,674.03 km) |
| Oro Valley to Southgate (Michigan) | 1,659.34 mi (2,670.44 km) |
| Oro Valley to Southlake (Texas) | 804.28 mi (1,294.37 km) |
| Oro Valley to Spanaway (Washington) | 1,179.52 mi (1,898.26 km) |
| Oro Valley to Spanish Fork (Utah) | 532.56 mi (857.07 km) |
| Oro Valley to Spanish Lake (Missouri) | 1,243.45 mi (2,001.14 km) |
| Oro Valley to Spanish Springs (Nevada) | 696.32 mi (1,120.61 km) |
| Oro Valley to Sparks (Nevada) | 694.22 mi (1,117.24 km) |
| Oro Valley to Spartanburg (South Carolina) | 1,673.49 mi (2,693.22 km) |
| Oro Valley to Spearfish (South Dakota) | 918.66 mi (1,478.44 km) |
| Oro Valley to Speedway (Indiana) | 1,465.52 mi (2,358.53 km) |
| Oro Valley to Spencer (Iowa) | 1,134.85 mi (1,826.37 km) |
| Oro Valley to Spokane (Washington) | 1,106.39 mi (1,780.57 km) |
| Oro Valley to Spokane Valley (Washington) | 1,102.97 mi (1,775.05 km) |
