| Orangeburg to Yonkers (New York) | 642.59 mi (1,034.15 km) |
| Orangeburg to Yorba Linda (California) | 2,110.14 mi (3,395.95 km) |
| Orangeburg to York (Pennsylvania) | 502.27 mi (808.32 km) |
| Orangeburg to Yorktown (Indiana) | 528.62 mi (850.73 km) |
| Orangeburg to Yorkville (Illinois) | 699.79 mi (1,126.20 km) |
| Orangeburg to Youngstown (Ohio) | 525.70 mi (846.03 km) |
| Orangeburg to Youngsville (Louisiana) | 693.99 mi (1,116.86 km) |
| Orangeburg to Ypsilanti (Michigan) | 622.92 mi (1,002.50 km) |
| Orangeburg to Yuba City (California) | 2,283.67 mi (3,675.21 km) |
| Orangeburg to Yucaipa (California) | 2,067.32 mi (3,327.03 km) |
| Orangeburg to Yucca Valley (California) | 2,031.23 mi (3,268.95 km) |
| Orangeburg to Yukon (Oklahoma) | 970.97 mi (1,562.62 km) |
| Orangeburg to Yulee (Florida) | 201.67 mi (324.56 km) |
| Orangeburg to Yuma (Arizona) | 1,943.12 mi (3,127.15 km) |
| Orangeburg to Zachary (Louisiana) | 633.33 mi (1,019.25 km) |
