| Orangeburg to University Place (Washington) | 2,355.97 mi (3,791.57 km) |
| Orangeburg to Upland (California) | 2,101.25 mi (3,381.63 km) |
| Orangeburg to Upper Arlington (Ohio) | 467.62 mi (752.56 km) |
| Orangeburg to Upper Grand Lagoon (Florida) | 366.78 mi (590.27 km) |
| Orangeburg to Upper Montclair (New Jersey) | 626.17 mi (1,007.73 km) |
| Orangeburg to Urbana (Illinois) | 610.71 mi (982.84 km) |
| Orangeburg to Urbana (Maryland) | 448.15 mi (721.23 km) |
| Orangeburg to Urbana (Ohio) | 484.12 mi (779.12 km) |
| Orangeburg to Urbandale (Iowa) | 902.16 mi (1,451.89 km) |
| Orangeburg to Utica (New York) | 730.20 mi (1,175.14 km) |
| Orangeburg to Uvalde (Texas) | 1,152.43 mi (1,854.66 km) |
| Orangeburg to Vacaville (California) | 2,304.89 mi (3,709.37 km) |
| Orangeburg to Vadnais Heights (Minnesota) | 1,029.44 mi (1,656.72 km) |
| Orangeburg to Vail (Arizona) | 1,730.13 mi (2,784.38 km) |
| Orangeburg to Valdosta (Georgia) | 230.70 mi (371.28 km) |
