| Orangeburg to Superior (Colorado) | 1,411.90 mi (2,272.23 km) |
| Orangeburg to Superior (Wisconsin) | 1,085.37 mi (1,746.73 km) |
| Orangeburg to Surprise (Arizona) | 1,810.79 mi (2,914.18 km) |
| Orangeburg to Susanville (California) | 2,226.49 mi (3,583.20 km) |
| Orangeburg to Sussex (Wisconsin) | 775.66 mi (1,248.30 km) |
| Orangeburg to Suwanee (Georgia) | 187.87 mi (302.34 km) |
| Orangeburg to Swansea (Illinois) | 617.39 mi (993.59 km) |
| Orangeburg to Sweetwater (Florida) | 533.82 mi (859.10 km) |
| Orangeburg to Sweetwater (Texas) | 1,133.18 mi (1,823.67 km) |
| Orangeburg to Sycamore (Illinois) | 725.54 mi (1,167.65 km) |
| Orangeburg to Sylacauga (Alabama) | 312.06 mi (502.21 km) |
| Orangeburg to Sylvania (Ohio) | 588.58 mi (947.24 km) |
| Orangeburg to Syosset (New York) | 647.92 mi (1,042.73 km) |
| Orangeburg to Syracuse (New York) | 707.39 mi (1,138.44 km) |
| Orangeburg to Syracuse (Utah) | 1,782.76 mi (2,869.07 km) |
