| Orangeburg to Storm Lake (Iowa) | 1,001.17 mi (1,611.23 km) |
| Orangeburg to Storrs (Connecticut) | 742.29 mi (1,194.61 km) |
| Orangeburg to Stoughton (Wisconsin) | 793.03 mi (1,276.27 km) |
| Orangeburg to Stow (Ohio) | 531.80 mi (855.85 km) |
| Orangeburg to Streamwood (Illinois) | 711.18 mi (1,144.54 km) |
| Orangeburg to Streator (Illinois) | 684.57 mi (1,101.71 km) |
| Orangeburg to Streetsboro (Ohio) | 535.89 mi (862.44 km) |
| Orangeburg to Strongsville (Ohio) | 542.88 mi (873.69 km) |
| Orangeburg to Stuart (Florida) | 436.65 mi (702.72 km) |
| Orangeburg to Stuarts Draft (Virginia) | 329.13 mi (529.68 km) |
| Orangeburg to Sturgis (Michigan) | 625.34 mi (1,006.39 km) |
| Orangeburg to Suamico (Wisconsin) | 860.51 mi (1,384.86 km) |
| Orangeburg to Sudley (Virginia) | 411.29 mi (661.90 km) |
| Orangeburg to Suffern (New York) | 642.85 mi (1,034.57 km) |
| Orangeburg to Suffolk (Virginia) | 325.62 mi (524.03 km) |
