| Orangeburg to Stephenville (Texas) | 1,009.91 mi (1,625.30 km) |
| Orangeburg to Sterling (Colorado) | 1,321.20 mi (2,126.27 km) |
| Orangeburg to Sterling (Illinois) | 749.25 mi (1,205.80 km) |
| Orangeburg to Sterling (Virginia) | 426.85 mi (686.94 km) |
| Orangeburg to Sterling Heights (Michigan) | 638.80 mi (1,028.05 km) |
| Orangeburg to Steubenville (Ohio) | 474.99 mi (764.43 km) |
| Orangeburg to Stevens Point (Wisconsin) | 892.26 mi (1,435.95 km) |
| Orangeburg to Stevenson Ranch (California) | 2,150.52 mi (3,460.93 km) |
| Orangeburg to Stillwater (Minnesota) | 1,021.35 mi (1,643.71 km) |
| Orangeburg to Stillwater (Oklahoma) | 936.11 mi (1,506.53 km) |
| Orangeburg to Stockbridge (Georgia) | 193.71 mi (311.75 km) |
| Orangeburg to Stockton (California) | 2,271.46 mi (3,655.56 km) |
| Orangeburg to Stone Ridge (Virginia) | 418.46 mi (673.44 km) |
| Orangeburg to Stonecrest (Georgia) | 188.67 mi (303.64 km) |
| Orangeburg to Stony Brook (New York) | 665.57 mi (1,071.14 km) |
