| Orangeburg to St. Simons (Georgia) | 162.81 mi (262.02 km) |
| Orangeburg to Stafford (Texas) | 904.67 mi (1,455.93 km) |
| Orangeburg to Stallings (North Carolina) | 112.28 mi (180.70 km) |
| Orangeburg to Stamford (Connecticut) | 661.20 mi (1,064.09 km) |
| Orangeburg to Stanford (California) | 2,321.62 mi (3,736.28 km) |
| Orangeburg to Stanton (California) | 2,123.75 mi (3,417.85 km) |
| Orangeburg to Star (Idaho) | 2,030.36 mi (3,267.55 km) |
| Orangeburg to Starkville (Mississippi) | 458.79 mi (738.35 km) |
| Orangeburg to State College (Pennsylvania) | 530.71 mi (854.10 km) |
| Orangeburg to Staten Island (New York) | 613.79 mi (987.81 km) |
| Orangeburg to Statesboro (Georgia) | 89.93 mi (144.72 km) |
| Orangeburg to Statesville (North Carolina) | 158.32 mi (254.79 km) |
| Orangeburg to Staunton (Virginia) | 337.90 mi (543.80 km) |
| Orangeburg to Steamboat Springs (Colorado) | 1,505.17 mi (2,422.34 km) |
| Orangeburg to Steiner Ranch (Texas) | 1,020.41 mi (1,642.19 km) |
