| Orangeburg to Spout Springs (North Carolina) | 161.41 mi (259.76 km) |
| Orangeburg to Spring (Texas) | 884.09 mi (1,422.80 km) |
| Orangeburg to Spring Creek (Nevada) | 1,964.06 mi (3,160.85 km) |
| Orangeburg to Spring Hill (Florida) | 360.08 mi (579.49 km) |
| Orangeburg to Spring Hill (Tennessee) | 377.15 mi (606.96 km) |
| Orangeburg to Spring Lake (North Carolina) | 158.27 mi (254.71 km) |
| Orangeburg to Spring Valley (California) | 2,079.78 mi (3,347.09 km) |
| Orangeburg to Spring Valley (Nevada) | 1,949.79 mi (3,137.88 km) |
| Orangeburg to Spring Valley (New York) | 645.88 mi (1,039.44 km) |
| Orangeburg to Springboro (Ohio) | 459.01 mi (738.70 km) |
| Orangeburg to Springdale (Arkansas) | 775.66 mi (1,248.30 km) |
| Orangeburg to Springdale (New Jersey) | 548.56 mi (882.82 km) |
| Orangeburg to Springdale (Ohio) | 447.98 mi (720.95 km) |
| Orangeburg to Springfield (Illinois) | 651.71 mi (1,048.83 km) |
| Orangeburg to Springfield (Massachusetts) | 748.59 mi (1,204.74 km) |
