| Orangeburg to Southern Pines (North Carolina) | 144.09 mi (231.89 km) |
| Orangeburg to Southfield (Michigan) | 634.17 mi (1,020.60 km) |
| Orangeburg to Southgate (Michigan) | 615.24 mi (990.13 km) |
| Orangeburg to Southlake (Texas) | 940.93 mi (1,514.28 km) |
| Orangeburg to Spanaway (Washington) | 2,349.09 mi (3,780.49 km) |
| Orangeburg to Spanish Fork (Utah) | 1,753.15 mi (2,821.43 km) |
| Orangeburg to Spanish Lake (Missouri) | 636.24 mi (1,023.92 km) |
| Orangeburg to Spanish Springs (Nevada) | 2,177.29 mi (3,504.02 km) |
| Orangeburg to Sparks (Nevada) | 2,179.90 mi (3,508.21 km) |
| Orangeburg to Spartanburg (South Carolina) | 117.09 mi (188.44 km) |
| Orangeburg to Spearfish (South Dakota) | 1,440.21 mi (2,317.79 km) |
| Orangeburg to Speedway (Indiana) | 527.50 mi (848.93 km) |
| Orangeburg to Spencer (Iowa) | 1,019.50 mi (1,640.73 km) |
| Orangeburg to Spokane (Washington) | 2,127.66 mi (3,424.14 km) |
| Orangeburg to Spokane Valley (Washington) | 2,118.63 mi (3,409.60 km) |
