| Orangeburg to Smyrna (Delaware) | 495.95 mi (798.15 km) |
| Orangeburg to Smyrna (Georgia) | 211.39 mi (340.20 km) |
| Orangeburg to Smyrna (Tennessee) | 363.96 mi (585.74 km) |
| Orangeburg to Snellville (Georgia) | 182.09 mi (293.05 km) |
| Orangeburg to Snoqualmie (Washington) | 2,326.79 mi (3,744.61 km) |
| Orangeburg to Snyder (Texas) | 1,159.60 mi (1,866.20 km) |
| Orangeburg to Socastee (South Carolina) | 107.81 mi (173.50 km) |
| Orangeburg to Socorro (Texas) | 1,480.50 mi (2,382.63 km) |
| Orangeburg to Soddy-Daisy (Tennessee) | 274.15 mi (441.21 km) |
| Orangeburg to Solana Beach (California) | 2,092.21 mi (3,367.08 km) |
| Orangeburg to Soledad (California) | 2,284.05 mi (3,675.82 km) |
| Orangeburg to Solon (Ohio) | 546.30 mi (879.19 km) |
| Orangeburg to Somers Point (New Jersey) | 531.79 mi (855.84 km) |
| Orangeburg to Somerset (Kentucky) | 325.71 mi (524.18 km) |
| Orangeburg to Somerset (New Jersey) | 598.24 mi (962.78 km) |
