| Orangeburg to Silver Firs (Washington) | 2,344.80 mi (3,773.59 km) |
| Orangeburg to Silver Spring (Maryland) | 436.78 mi (702.92 km) |
| Orangeburg to Silver Springs Shores (Florida) | 310.13 mi (499.10 km) |
| Orangeburg to Silverdale (Washington) | 2,367.01 mi (3,809.34 km) |
| Orangeburg to Silverton (Oregon) | 2,349.26 mi (3,780.78 km) |
| Orangeburg to Simi Valley (California) | 2,160.95 mi (3,477.71 km) |
| Orangeburg to Simpsonville (South Carolina) | 116.67 mi (187.76 km) |
| Orangeburg to Sioux City (Iowa) | 1,046.68 mi (1,684.47 km) |
| Orangeburg to Sioux Falls (South Dakota) | 1,100.03 mi (1,770.33 km) |
| Orangeburg to Skokie (Illinois) | 698.97 mi (1,124.88 km) |
| Orangeburg to Sleepy Hollow (New York) | 650.36 mi (1,046.65 km) |
| Orangeburg to Slidell (Louisiana) | 567.68 mi (913.60 km) |
| Orangeburg to Smithfield (North Carolina) | 200.08 mi (322.00 km) |
| Orangeburg to Smithfield (Utah) | 1,777.35 mi (2,860.36 km) |
| Orangeburg to Smithville (Missouri) | 862.72 mi (1,388.42 km) |
