| Orangeburg to Seymour (Tennessee) | 233.02 mi (375.01 km) |
| Orangeburg to Shady Hills (Florida) | 365.39 mi (588.03 km) |
| Orangeburg to Shafter (California) | 2,173.81 mi (3,498.41 km) |
| Orangeburg to Shaker Heights (Ohio) | 552.74 mi (889.55 km) |
| Orangeburg to Shakopee (Minnesota) | 1,029.17 mi (1,656.29 km) |
| Orangeburg to Sharon (Pennsylvania) | 535.24 mi (861.39 km) |
| Orangeburg to Sharonville (Ohio) | 445.76 mi (717.38 km) |
| Orangeburg to Shasta Lake (California) | 2,318.85 mi (3,731.83 km) |
| Orangeburg to Shawnee (Kansas) | 864.09 mi (1,390.62 km) |
| Orangeburg to Shawnee (Oklahoma) | 925.37 mi (1,489.24 km) |
| Orangeburg to Sheboygan (Wisconsin) | 798.44 mi (1,284.97 km) |
| Orangeburg to Shelby (North Carolina) | 130.08 mi (209.34 km) |
| Orangeburg to Shelbyville (Indiana) | 498.51 mi (802.27 km) |
| Orangeburg to Shelbyville (Kentucky) | 407.02 mi (655.03 km) |
| Orangeburg to Shelbyville (Tennessee) | 346.83 mi (558.17 km) |
