| Orangeburg to Security-Widefield (Colorado) | 1,375.18 mi (2,213.14 km) |
| Orangeburg to Sedalia (Missouri) | 777.76 mi (1,251.68 km) |
| Orangeburg to Sedro-Woolley (Washington) | 2,356.45 mi (3,792.33 km) |
| Orangeburg to Seguin (Texas) | 1,041.08 mi (1,675.46 km) |
| Orangeburg to Selden (New York) | 666.66 mi (1,072.89 km) |
| Orangeburg to Selma (Alabama) | 365.10 mi (587.57 km) |
| Orangeburg to Selma (California) | 2,187.69 mi (3,520.74 km) |
| Orangeburg to Selma (Texas) | 1,060.74 mi (1,707.09 km) |
| Orangeburg to Seminole (Florida) | 406.59 mi (654.34 km) |
| Orangeburg to Seven Hills (Ohio) | 546.76 mi (879.92 km) |
| Orangeburg to Seven Oaks (South Carolina) | 41.48 mi (66.76 km) |
| Orangeburg to Severn (Maryland) | 453.67 mi (730.11 km) |
| Orangeburg to Severna Park (Maryland) | 454.51 mi (731.46 km) |
| Orangeburg to Sevierville (Tennessee) | 225.61 mi (363.09 km) |
| Orangeburg to Seymour (Indiana) | 469.36 mi (755.36 km) |
