| Orangeburg to Scottsboro (Alabama) | 307.03 mi (494.11 km) |
| Orangeburg to Scottsdale (Arizona) | 1,777.38 mi (2,860.41 km) |
| Orangeburg to Scranton (Pennsylvania) | 616.33 mi (991.89 km) |
| Orangeburg to Seabrook (Maryland) | 440.18 mi (708.40 km) |
| Orangeburg to Seabrook (Texas) | 875.64 mi (1,409.20 km) |
| Orangeburg to Seaford (New York) | 640.59 mi (1,030.92 km) |
| Orangeburg to Seagoville (Texas) | 908.75 mi (1,462.49 km) |
| Orangeburg to Seal Beach (California) | 2,128.71 mi (3,425.83 km) |
| Orangeburg to Searcy (Arkansas) | 631.15 mi (1,015.73 km) |
| Orangeburg to Seaside (California) | 2,308.83 mi (3,715.71 km) |
| Orangeburg to SeaTac (Washington) | 2,346.92 mi (3,777.01 km) |
| Orangeburg to Seattle (Washington) | 2,350.05 mi (3,782.03 km) |
| Orangeburg to Sebastian (Florida) | 395.23 mi (636.06 km) |
| Orangeburg to Sebring (Florida) | 417.11 mi (671.27 km) |
| Orangeburg to Secaucus (New Jersey) | 627.17 mi (1,009.33 km) |
