| Orangeburg to Savannah (Georgia) | 102.81 mi (165.45 km) |
| Orangeburg to Sayreville (New Jersey) | 601.71 mi (968.37 km) |
| Orangeburg to Sayville (New York) | 659.06 mi (1,060.66 km) |
| Orangeburg to Scaggsville (Maryland) | 448.76 mi (722.20 km) |
| Orangeburg to Scarsdale (New York) | 647.89 mi (1,042.67 km) |
| Orangeburg to Schaumburg (Illinois) | 708.88 mi (1,140.83 km) |
| Orangeburg to Schenectady (New York) | 744.97 mi (1,198.91 km) |
| Orangeburg to Schererville (Indiana) | 659.09 mi (1,060.70 km) |
| Orangeburg to Schertz (Texas) | 1,057.84 mi (1,702.43 km) |
| Orangeburg to Schiller Park (Illinois) | 698.40 mi (1,123.97 km) |
| Orangeburg to Schofield Barracks (Hawaii) | 4,700.19 mi (7,564.23 km) |
| Orangeburg to Scotchtown (New York) | 656.26 mi (1,056.15 km) |
| Orangeburg to Scottdale (Georgia) | 196.46 mi (316.17 km) |
| Orangeburg to Scotts Valley (California) | 2,315.87 mi (3,727.03 km) |
| Orangeburg to Scottsbluff (Nebraska) | 1,368.61 mi (2,202.57 km) |
