| Orangeburg to Santa Rosa (California) | 2,344.32 mi (3,772.82 km) |
| Orangeburg to Santaquin (Utah) | 1,760.39 mi (2,833.08 km) |
| Orangeburg to Santee (California) | 2,078.58 mi (3,345.15 km) |
| Orangeburg to Sapulpa (Oklahoma) | 881.11 mi (1,418.00 km) |
| Orangeburg to Saraland (Alabama) | 460.68 mi (741.39 km) |
| Orangeburg to Sarasota (Florida) | 436.76 mi (702.89 km) |
| Orangeburg to Sarasota Springs (Florida) | 437.87 mi (704.68 km) |
| Orangeburg to Saratoga (California) | 2,315.05 mi (3,725.71 km) |
| Orangeburg to Saratoga Springs (New York) | 764.48 mi (1,230.32 km) |
| Orangeburg to Saratoga Springs (Utah) | 1,769.13 mi (2,847.14 km) |
| Orangeburg to Sartell (Minnesota) | 1,096.03 mi (1,763.89 km) |
| Orangeburg to Satellite Beach (Florida) | 367.54 mi (591.50 km) |
| Orangeburg to Sauk Rapids (Minnesota) | 1,092.74 mi (1,758.60 km) |
| Orangeburg to Sault Ste. Marie (Michigan) | 916.18 mi (1,474.44 km) |
| Orangeburg to Savage (Minnesota) | 1,024.24 mi (1,648.36 km) |
