| Orangeburg to Sanford (Maine) | 876.13 mi (1,409.99 km) |
| Orangeburg to Sanford (North Carolina) | 168.09 mi (270.52 km) |
| Orangeburg to Sanger (California) | 2,183.64 mi (3,514.22 km) |
| Orangeburg to Santa Ana (California) | 2,118.21 mi (3,408.92 km) |
| Orangeburg to Santa Barbara (California) | 2,213.74 mi (3,562.67 km) |
| Orangeburg to Santa Clara (California) | 2,311.17 mi (3,719.46 km) |
| Orangeburg to Santa Clara (Oregon) | 2,362.13 mi (3,801.49 km) |
| Orangeburg to Santa Clarita (California) | 2,145.04 mi (3,452.10 km) |
| Orangeburg to Santa Cruz (California) | 2,317.72 mi (3,730.01 km) |
| Orangeburg to Santa Fe (New Mexico) | 1,432.67 mi (2,305.66 km) |
| Orangeburg to Santa Fe (Texas) | 884.73 mi (1,423.84 km) |
| Orangeburg to Santa Fe Springs (California) | 2,126.08 mi (3,421.59 km) |
| Orangeburg to Santa Maria (California) | 2,248.65 mi (3,618.85 km) |
| Orangeburg to Santa Monica (California) | 2,148.64 mi (3,457.91 km) |
| Orangeburg to Santa Paula (California) | 2,177.77 mi (3,504.78 km) |
