| Orangeburg to Saddlebrooke (Arizona) | 1,733.45 mi (2,789.72 km) |
| Orangeburg to Safety Harbor (Florida) | 394.20 mi (634.40 km) |
| Orangeburg to Saginaw (Michigan) | 705.74 mi (1,135.78 km) |
| Orangeburg to Saginaw (Texas) | 954.05 mi (1,535.40 km) |
| Orangeburg to Sahuarita (Arizona) | 1,746.97 mi (2,811.48 km) |
| Orangeburg to Saks (Alabama) | 287.33 mi (462.42 km) |
| Orangeburg to Salem (Massachusetts) | 825.08 mi (1,327.83 km) |
| Orangeburg to Salem (Ohio) | 512.13 mi (824.19 km) |
| Orangeburg to Salem (Oregon) | 2,360.67 mi (3,799.13 km) |
| Orangeburg to Salem (Virginia) | 266.07 mi (428.19 km) |
| Orangeburg to Salem Lakes (Wisconsin) | 738.78 mi (1,188.95 km) |
| Orangeburg to Salida (California) | 2,260.70 mi (3,638.24 km) |
| Orangeburg to Salina (Kansas) | 1,002.14 mi (1,612.78 km) |
| Orangeburg to Salinas (California) | 2,297.93 mi (3,698.16 km) |
| Orangeburg to Salisbury (Maryland) | 448.26 mi (721.40 km) |
