| Orangeburg to Oswego (Illinois) | 697.61 mi (1,122.69 km) |
| Orangeburg to Oswego (New York) | 727.21 mi (1,170.34 km) |
| Orangeburg to Otsego (Minnesota) | 1,058.24 mi (1,703.07 km) |
| Orangeburg to Ottawa (Illinois) | 696.36 mi (1,120.68 km) |
| Orangeburg to Ottawa (Kansas) | 876.95 mi (1,411.31 km) |
| Orangeburg to Ottumwa (Iowa) | 819.70 mi (1,319.18 km) |
| Orangeburg to Overland (Missouri) | 640.29 mi (1,030.44 km) |
| Orangeburg to Overland Park (Kansas) | 854.77 mi (1,375.62 km) |
| Orangeburg to Overlea (Maryland) | 472.12 mi (759.80 km) |
| Orangeburg to Oviedo (Florida) | 334.59 mi (538.47 km) |
| Orangeburg to Owasso (Oklahoma) | 868.80 mi (1,398.20 km) |
| Orangeburg to Owatonna (Minnesota) | 987.51 mi (1,589.25 km) |
| Orangeburg to Owensboro (Kentucky) | 458.10 mi (737.24 km) |
| Orangeburg to Owings Mills (Maryland) | 467.35 mi (752.12 km) |
| Orangeburg to Owosso (Michigan) | 680.52 mi (1,095.20 km) |
